Active Recombinant Mouse Vtcn1, Fc-tagged

• Cat.No.: Vtcn1-12M
• Product Overview: Recombinant Mouse Vtcn1 (aa 29-258) is fused to the N-terminus of the Fc region of mouse IgG2a.

Specification

• Species: Mouse
• Source: CHO
• Tag: Fc
• Protein Length: 29-258 a.a.
• Description: V-set domain-containing T-cell activation inhibitor 1 is a protein that in humans is encoded by the VTCN1 gene. B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ablility to inhibit anti-CD3-induced proliferation of stimulated mouse T cells.
• Endotoxin: <0.06EU/μg protein (LAL test; Lonza).
• Purity: ≥98% (SDS-PAGE)
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Storage: Short Term Storage: +4°CLong Term Storage: -20°CHandling Advice: Avoid freeze/thaw cycles.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.

Gene Information

• Gene Name: Vtcn1 V-set domain containing T cell activation inhibitor 1 [ Mus musculus (house mouse) ]
• Official Symbol: Vtcn1
• Synonyms: Vtcn1; B7x; B7h4; B7s1; BC032925; V-set domain containing T cell activation inhibitor 1; V-set domain containing T-cell activation inhibitor 1; t cell costimulatory molecule B7x; immune costimulatory protein B7-H4
• Gene ID: 242122
• mRNA Refseq: NM_178594
• Protein Refseq: NP_848709
• UniProt ID: Q7TSP5
• Chromosome Location: 3 F2.2; 3
• Pathway: Cell adhesion molecules (CAMs)
• Function: receptor binding