Active Recombinant Mouse V-Erb-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (avian), Fc-tagged

• Cat.No.: Erbb3-470M
• Product Overview: Recombinant Mouse Erbb3protein was expressed in Murine myeloma cell line with the Fc part of mouse IgG2a.Ser20-His641.

Specification

• Cat. No.: Erbb3-470M
• Description: Erbb3, also called HER3(human epidermal growth factor receptor 3) in humans, is a type I transmembraneglycoprotein that is a member of the ErbB family of tyrosine kinase receptorsnamed for a viral oncogene. ErbB family members serve as receptors for the EGFfamily of growth factors. Mouse Erbb3 contains a 19 amino acid (aa) signal sequence,a 622 aa extracellular domain (ECD), a 24 aa transmembrane region, and a 677 aacytoplasmic domain.
• Source: Mammalian cells
• Form: Lyophilized from a 0.2μm filtered solution in PBS.
• N-terminalSequence: Ser20
• Molecular Weight: 95.6 kDa
• Activity: Measuredby its ability to bind rhNRG1ß1 extracellular domain in a functional ELISA withan estimated KD < 15 nM.
• Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
• Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: Reconstituteat 100 μg/mL in sterile PBS
• Storage: Use a manualdefrost freezer and avoid repeated freezethaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3 months,-20 to -70°C under sterile conditions after reconstitution.
• Protein length: 20-641 a.a.

Gene Information

• Gene Name: Erbb3 v-erb-b2 erythroblastic leukemiaviral oncogene homolog 3 (avian) [ Mus musculus ]
• Official Symbol: Erbb3
• Synonyms: Erbb3; v-erb-b2erythroblastic leukemia viral oncogene homolog 3 (avian); Her3; C76256; Erbb-3;Erbb3r; receptor tyrosine-protein kinase erbB-3; c-erbB-3; receptor tyrosine kinase;glial growth factor receptor; proto-oncogene-like protein c-ErbB-3; avian erythroblastosisoncogene B 3 receptor; EC 2.7.10.1
• Gene ID: 13867
• mRNA Refseq: NM_010153
• Protein Refseq: NP_034283
• UniProt ID: Q61526
• Chromosome Location: 10 D3; 10 70.0 cM
• Pathway: Calcium signaling pathway;Endocytosis; ErbB signaling pathway; IL-6 signaling Pathway
• Function: ATP binding; growth factorbinding; kinase activity; nucleotide binding; protein binding; protein heterodimerizationactivity; protein kinase activity; protein tyrosine kinase activator activity;NOT protein tyrosine kinase activity; receptor activity; receptor signaling proteintyrosine kinase activity; transferase activity; transferase activity; transmembranereceptor protein tyrosine kinase activity