Active Recombinant Mouse Met Protein, Fc/His-tagged, Alexa Fluor 647 conjugated

• Cat.No.: Met-1744MAF647
• Product Overview: Alexa Fluor 647 conjugated recombinant Mouse HGFR (Met 1-Asn 929) - Linker peptide (DIEGRMD) - Human IgG1 (Pro 100 - Lys 330) - 6x His Tag was produced inSf 21 Insect Cell.

Specification

• Description: Hepatocyte growth factor receptor (HGFR), also known as c-Met, plays an important roles in angiogenesis and tumor growth. C-Met is a receptor tyrosine kinase expressed by epithelial cells of the brain, kidney, liver and other tissues. Binding of its ligand, Hepatocyte Growth Factor (HGF), triggers receptor autophosphorylation, and activation of several downstream effectors including the mitogen-activated protein kinases ERK-1 and ERK-2, and PLC-γ. Activation of the c-Met signal transduction pathway leads to mulitple cellular responses including cell motility, scattering, proliferation, survival and angiogenesis.
• Source: Insect Cells
• Species: Mouse
• Tag: His&Fc
• Form: Lyophilized
• Bio-activity: Measured by its ability to bind rmHGF in a functional ELISA type binding assay with an estimated KD < 0.2 nM.
• Molecular Mass: 128 kDa
• Endotoxin: < 0.1 EU/ μg as determined by the LAL method.
• Purity: > 95 % by SDS-PAGE and analyzed by silver stain.
• Characteristic: Disulfide-linked homodimer
  Labeled with Alexa Fluor 647 via amines
  Excitation = 650 nm
  Emission = 668 nm
• Stability: This lyophilized protein is stable for 6 to 12 months when stored desiccated at -20 to -70 centigrade. After aseptic reconstitution, this protein may be stored at 2 to 8 centigrade for one month or at -20 to -70 centigrade in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
• Storage: This lyophilized protein is stable for six to twelve months when stored desiccated at -20 to -70 centigrade. After aseptic reconstitution, this protein may be stored at 2 to 8 centigrade for one month or at -20 to -70 centigrade in a manual defrost freezer.
• Protein length: 1-929 a.a.

Gene Information

• Gene Name: Met met proto-oncogene [ Mus musculus ]
• Official Symbol: Met
• Synonyms: Met; met proto-oncogene; HGF; HGFR; Par4; c-Met; AI838057; HGF receptor OTTMUSP00000028498; OTTMUSP00000028499
• Gene ID: 17295
• mRNA Refseq: NM_008591
• Protein Refseq: NP_032617
• UniProt ID: P16056