Active Recombinant Mouse Frizzled Homolog 2 (Drosophila), Fc-tagged

• Cat.No.: Fzd2-585M
• Product Overview: RecombinantMouse Fzd2 protein was expressed in Murine myeloma cell line with the Fc partof Human IgG1 Pro100-Lys330 (C-terminus) and Mouse Frizzled-2 Gln29-Leu168 (N-terminus).

Specification

• Species: Mouse
• Source: Mammalian Cells
• Tag: Fc
• Protein Length: 29-168 a.a.
• Description: Fzd2 is involved invariety of developmental processes including cell fate determination, cellpolarity, tissue patterning and control of cell proliferation. Members of theFrizzled family of proteins serve as receptors for the Wnt signaling pathway.
• Form: Supplied as a 0.2 μmfiltered solution in PBS.
• N-terminal Sequence: Gln29 predicted
• Molecular Weight: 42.3 kDa
• Activity: Measured by itsability to bind biotinylated Wnt-5a in a functional ELISA with an estimated KD< 5 nM.
• Endotoxin Level: <1.0 EU per 1 μgof the protein by the LAL method.
• SDS-PAGE: 50-55 kDa, reducingconditions
• Purity: >90%, by SDS-PAGEunder reducing conditions and visualized by silver stain.
• Reconstitution: Reconstitute at 100μg/mL in sterile PBS.
• Storage: Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1month, 2 to 8 °C under sterile conditions after reconstitution.3 months, -20 to-70 °C under sterile conditions after reconstitution.

Gene Information

• Gene Name: Fzd2 frizzled homolog 2(Drosophila) [ Mus musculus ]
• Official Symbol: Fzd2
• Synonyms: Fzd2; frizzledhomolog 2 (Drosophila); Fz10; Fzd10; Mfz10; Mfz10a; AL033370;AW456835; OTTMUSP00000002857; frizzled-2; fz-2;mFz2; fz-10; frizzled-10
• Gene ID: 57265
• mRNA Refseq: NM_020510
• Protein Refseq: NP_065256
• UniProt ID: Q9JIP6
• Chromosome Location: 11
• Pathway: Basal cellcarcinoma; Class B/2 (Secretin family receptors); GPCR ligand binding; HTLV-Iinfection; Melanogenesis; Pathways in cancer; Signal Transduction; Signalingby GPCR; Wnt Signaling Pathway; Wnt signaling network
• Function: G-protein coupledreceptor activity; PDZ domain binding; Wnt-activated receptor activity;Wnt-protein binding; protein binding; protein heterodimerization activity;receptor activity; signal transducer activity; transmembrane signalingreceptor activity