Active Recombinant Mouse Cytotoxic And Regulatory T Cell Molecule, Fc-tagged

• Cat.No.: Crtam-5613M
• Product Overview: Recombinant Mouse Crtamprotein was expressed in Murine myeloma cell line with the Fc part of humanIgG1 Pro100-Lys330 (C-terminus) and Ala17-Ser284 (N-terminus).

Specification

• Cat. No.: Crtam-5613M
• Description: Crtam (ClassIrestricted T cellassociated molecule) is a member of the nectin family ofthe immunoglobulin superfamily. It is expressed by activated CD8+ and NK Tcells. NK activation receptor engagement, but not cytokines, also inducesCratm expression on NK cells. Crtam is found in spleen, thymus, smallintestine, peripheral blood, and surprisingly, in brain where it is highlyexpressed by Purkinje cells of the cerebellum.
• Source: Mammalian cells
• Form: Lyophilized from a 0.2μm filtered solution in PBS.
• N-terminalSequence: Ala17
• Molecular Weight: 56.1 kDa
• Activity: Measuredby its binding activity in a functional ELISA. Galiberet, L. et al. (2005) J.Biol. Chem. 280:21955. Immobilized rmCrtam/Fc Chimera at 2 μg/mL (100 μL/well)can bind rmIGSF4A with a linear range of 0.15-10 μg/mL
• Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
• SDS-PAGE: 90 kDa,reducing conditions
• Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: Reconstituteat 100 μg/mL in sterile PBS
• Storage: Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.
• Protein length: 17-284 a.a.

Gene Information

• Gene Name: Crtam cytotoxic and regulatoryT cell molecule [ Mus musculus ]
• Official Symbol: Crtam
• Synonyms: Crtam; cytotoxicand regulatory T cell molecule; MGC141606, MGC141607; cytotoxic andregulatory T-cell molecule; class I-restricted T cell-associated molecule;class-I MHC-restricted T-cell-associated molecule; CD355
• Gene ID: 54698
• mRNA Refseq: NM_019465
• Protein Refseq: NP_062338
• UniProt ID: Q149L7
• Chromosome Location: 9 A5.1; 9 20.5 cM
• Pathway: Adaptive ImmuneSystem; Immune System; Immunoregulatory interactions between a Lymphoid and anon-Lymphoid cell
• Function: protein binding;receptor binding