Active Recombinant Mouse Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (granulocyte-macrophage), His-tagged

• Cat.No.: Csf2ra-5615M
• Product Overview: Recombinant Mouse Csf2raprotein was expressed in Murine myeloma cell line with aC-terminal 6-His tag. Leu30-Pro327.

Specification

• Cat. No.: Csf2ra-5615M
• Description: Csf2ra, also knownas CD116, is a component of the receptor complex that mediates cellularresponses to GMCSF. GMCSF promotes the differentiation and mobilization ofgranulocyte-macrophage, erythroid, megakaryocyte, and eosinophil progenitors.It enhances the activation of myeloid cell effector functions and plays arole in the development of Th1 biased immune responses, allergicinflammation, and autoimmunity.
• Source: Mammalian cells
• Form: Lyophilized from a0.2 μm filtered solution in PBS.
• N-terminalSequence: Leu30
• Molecular Weight: 32.8 kDa
• Activity: Measuredby its ability to inhibit GM-CSF-dependent proliferation of DA3 mouse myelomacells. The ED50 for this effect is typically 0.5-3 μg/mL in thepresence of 0.1 ng/mL of rmGM-CSF.
• Endotoxin Level: <1.0 EUper 1 μg of the protein by the LAL method.
• SDS-PAGE: 55-65kDa, reducing conditions
• Purity: >95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: Reconstituteat 500 μg/mL in PBS
• Storage: Use a manualdefrost freezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8 °C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions after reconstitution.
• Protein length: 30-327 a.a.

Gene Information

• Gene Name: Csf2ra colony stimulatingfactor 2 receptor, alpha, low-affinity (granulocyte-macrophage) [ Musmusculus ]
• Official Symbol: Csf2ra
• Synonyms: Csf2ra; colonystimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage); CD116;Csfgmra; GM-CSFR; GM-CSF-Ra; granulocyte-macrophage colony-stimulating factorreceptor subunit alpha; GMR-alpha; GM-CSFRalpha; GMCSFR-alpha;GM-CSF-R-alpha; colony stimulating factor 2 receptor alpha chain
• Gene ID: 12982
• mRNA Refseq: NM_009970
• Protein Refseq: NP_034100
• UniProt ID: Q00941
• Chromosome Location: 19 D3; 19 51.0 cM
• Pathway: Cytokine Signalingin Immune system; Cytokine-cytokine receptor interaction; Hematopoietic celllineage; Immune System; Interleukin receptor SHC signaling; Interleukin-2signaling; Interleukin-3, 5 and GM-CSF signaling; Jak-STAT signaling pathway;Pathways in cancer; Signaling by Interleukins
• Function: cytokine receptoractivity; receptor activity