Active Recombinant Human VEGFD Protein

• Cat.No.: VEGFD-109H
• Product Overview: The mature recombinant human VEGF-B protein (93-201aa) without tag was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C. Read-through transcription has been observed between this locus and the upstream PIR (GeneID 8544) locus.
• Source: E. coli
• Species: Human
• Bio-activity: Measured in a cell proliferation assay using HMVEC human microvascular endothelial cells. The ED50 for this effect is 0.1-0.3 μg/mL. Measured by its binding ability in a functional ELISA. Immobilized recombinant human Flt-4 Fc Chimera at 5 μg/mL (100 μL/well) binds Recombinant Human VEGF-D with an apparent KD <15 nM.
• Molecular Mass: 13 kDa
• Product-Related Proteins: 93-201
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: VEGFD vascular endothelial growth factor D [ Homo sapiens (human) ]
• Official Symbol: VEGFD
• Synonyms: VEGFD; vascular endothelial growth factor D; FIGF; VEGF-D; vascular endothelial growth factor D; Names; c-fos induced growth factor (vascular endothelial growth factor D)
• Gene ID: 2277
• mRNA Refseq: NM_004469
• Protein Refseq: NP_004460
• MIM: 300091
• UniProt ID: O43915