Active Recombinant Human Upstream Transcription Factor 1, GST-tagged

• Cat.No.: USF1-1203H

Specification

• Cat. No.: USF1-1203H
• Description: Human Upstream Stimulatory Factor 1 (USF1) regulates the transcription of many genes involved in lipid and glucose homeostasis and co-localizes with familial combined hyperlipidemia (FCHL) and type 2-diabetes on chromosome 1q22-23. The USF1 protein can activate transcription through pyrimidine-rich initiator (Inr) elements and E-box motifs. It is a basic helix-loop-helix leucine zipper (b-HLH-ZIP) protein that shares a common DNA-binding specificity with the c-Myc oncoproteins.
• Source: E. coli.
• Form: Liquid. Supplied in 20 mM Tris-HCl pH 8.0, 20% glycerol, 100 mM KCl, 0.2 mM EDTA and 1 mM DTT.
• Purity: >95% by SDS-PAGE.
• Activity: 5-50 ng are sufficient for DNA binding assays, 50-500 ng are required for in vitro transcription assays and 100 ng are required for protein-protein interaction assays.
• Usage: For in vitro use only.
• Storage: Quality guaranteed for 12 months store at -80°C. Avoid freeze / thaw cycles.

Gene Information

• Gene Name: USF1 upstream transcription factor 1 [ Homo sapiens ]
• Synonyms: USF1; upstream transcription factor 1; UEF; FCHL; MLTF; FCHL1; MLTFI; HYPLIP1; bHLHb11; OTTHUMP00000029691; OTTHUMP00000029693; USF; Major late transcription factor 1; upstream stimulatory factor 1
• Gene ID: 7391
• mRNA Refseq: NM_007122
• Protein Refseq: NP_009053
• MIM: 191523
• UniProt ID: P22415
• Chromosome Location: 1q22-q23
• Function: RNA polymerase II transcription factor activity, enhancer binding; RNA polymerase II transcription factor activity, enhancer binding; bHLH transcription factor binding; double-stranded DNA binding; histone deacetylase binding; protein heterodimerization activity; protein homodimerization activity; protein homodimerization activity; protein kinase binding; sequence-specific DNA binding; transcription activator activity