Active Recombinant Human TNFRSF9 Protein, His-Tagged

• Cat.No.: TNFRSF9-01H
• Product Overview: Recombinant Human TNFRSF9 Protein, His-Tagged was expressed in Mouse myeloma cell line

Specification

• Species: Human
• Source: NS0
• Tag: His
• Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
• Form: Lyophilized
• Bio-activity: Measured by its binding ability in a functional ELISA. When recombinant human 4-1BB Fc Chimera is Immobilized at 10 ng/mL (100 µL/well), the concentration of recombinant human 4-1BB Ligand that produces 50% optimal binding response is found to be approximately 0.5‑2.5 ng/mL.
• Molecular Mass: 44.8 kDa (monomer)
• N-terminal Sequence Analysis: Leu24
• Endotoxin: <0.01 EU per 1 μg of the protein by the LAL method.
• Purity: >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 °C as supplied.
  1 month, 2 to 8 °C under sterile conditions after reconstitution.
  3 months, -20 to -70 °C under sterile conditions after reconstitution.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution in PBS.
• Reconstitution: Reconstitute at 100 μg/mL in sterile PBS.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Gene Information

• Gene Name: TNFRSF9 TNF receptor superfamily member 9 [ Homo sapiens (human) ]
• Official Symbol: TNFRSF9
• Synonyms: 4-1BB ligand receptor; 41BB; 4-1BB; CD137 antigen; CD137; CD137MGC2172; CDw137; FLJ43501; ILA; ILAhomolog of mouse 4-1BB; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB; T cell antigen ILA; T-cell antigen 4-1BB homolog; T-cell antigen ILA; TNFRSF9; tumor necrosis factor receptor superfamily member 9; tumor necrosis factor receptor superfamily, member 9
• Gene ID: 3604
• mRNA Refseq: NM_001561.6
• Protein Refseq: NP_001552.2
• MIM: 602250
• UniProt ID: Q07011