Active Recombinant Human TNFRSF4 Protein, Fc-tagged, Alexa Fluor® 647 conjugated

• Cat.No.: TNFRSF4-20H
• Product Overview: Recombinant human Alexa Fluor® 647 conjugated OX40 (Leu29-Ala216) protein with human IgG1 (Pro100-Lys330) Fc tag at C-terminus was expressed in mouse myeloma cell line.

Specification

• Species: Human
• Source: NS0
• Tag: Fc
• Protein Length: 29-216 a.a.
• Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation.
• Form: Disulfide-linked homodimer
  Labeled with Alexa Fluor® 647
  Excitation Wavelength: 650 nm
  Emission Wavelength: 668 nm
• Bio-activity: Measured by flow cytometry for its ability to bind anti-Human OX40/TNFRSF4 Monoclonal Antibody conjugated beads. The concentration of Recombinant Human OX40/TNFRSF4 Fc Chimera Alexa Fluor® 647 that produces 50% of the binding response is 1.5-15 ng/mL.
• Molecular Mass: 46.7 kDa
• N-terminal Sequence Analysis: Leu29
• Endotoxin: <1.0 EU/μg of the protein by the LAL method.
• Purity: >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Storage: Protect from light. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  6 months from date of receipt, -20 to -70 centigrade as supplied.
  1 month, 2 to 8 centigrade under sterile conditions after opening.
  3 months, -20 to -70 centigrade under sterile conditions after opening.
• Storage Buffer: Supplied as a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Shipping: The product is shipped with dry ice or equivalent.

Gene Information

• Gene Name: TNFRSF4 TNF receptor superfamily member 4 [ Homo sapiens (human) ]
• Official Symbol: TNFRSF4
• Synonyms: TNFRSF4; TNF receptor superfamily member 4; OX40; ACT35; CD134; IMD16; TXGP1L; tumor necrosis factor receptor superfamily member 4; ACT35 antigen; ATC35 antigen; CD134 antigen; OX40 antigen; OX40 cell surface antigen; OX40 homologue; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; lymphoid activation antigene ACT35; tax-transcriptionally activated glycoprotein 1 receptor
• Gene ID: 7293
• mRNA Refseq: NM_003327
• Protein Refseq: NP_003318
• MIM: 600315
• UniProt ID: P43489