Active Recombinant Human TNFRSF18, Fc-tagged, Biotinylated
| Cat.No. : | TNFRSF18-618H |
| Product Overview : | The recombinant human GITR-Fc fusion is expressed as a 364 amino acid protein consisting of Gln26 - Glu161 region of GITR (UniProt accession #Q9Y5U5) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions. |
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| Source : | Human cells |
| Species : | Human |
| Tag : | Fc |
| Form : | Supplied at 0.5 mg/ml in sterile PBSpH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule). |
| Bio-activity : | Binds to its ligand GITRL/TNFSF18 and blocks GITRL-induced signaling activity. |
| Molecular Mass : | Calculated molecular mass (kDa): 40.1; Estimated by SDS-PAGE under reducing condition (kDa): 45-50 |
| Endotoxin : | <0.1 eu="" per="" 1="" μg="" of="" purified="" recombinant="" protein="" determined="" by="" the="" lal=""> |
| Purity : | >95% judged by SDS-PAGE under reducing condition |
| Storage : | The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles. |
| Protein length : | 26-161 a.a. |
| Gene Name | TNFRSF18 tumor necrosis factor receptor superfamily, member 18 [ Homo sapiens ] |
| Official Symbol | TNFRSF18 |
| Synonyms | TNFRSF18; tumor necrosis factor receptor superfamily, member 18; tumor necrosis factor receptor superfamily member 18; AITR; CD357; GITR; activation-inducible TNFR family receptor; glucocorticoid-induced TNFR-related protein; TNF receptor superfamily activation-inducible protein; GITR-D; |
| Gene ID | 8784 |
| mRNA Refseq | NM_004195 |
| Protein Refseq | NP_004186 |
| MIM | 603905 |
| UniProt ID | Q9Y5U5 |
| Chromosome Location | 1p36.3 |
| Pathway | Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem; |
| Function | binding; receptor activity; tumor necrosis factor-activated receptor activity; |
Not For Human Consumption!
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