Active Recombinant Human TNFRSF17 Protein, Fc-tagged, Alexa Fluor 555 conjugated

• Cat.No.: TNFRSF17-2070HAF555
• Product Overview: Alexa Fluor 555 conjugated recombinant human TNFRSF17 is produced inHEK 293 Cellswith the C-terminus to the Fc portion of human IgG1. MW=42kDa.

Specification

• Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.
• Source: HEK293
• Species: Human
• Tag: Fc
• Form: Lyophilized
• Bio-activity: Blocks the binding of BAFF and APRIL to their receptors BCMA and TACI, inhibiting BAFF- and APRIL-mediated B cell activation.
• Endotoxin: < 0.1 EU/ μg purified protein (LAL test; BioWhittaker).
• Purity: ≥95 % by SDS-PAGE
• Characteristic: Disulfide-linked homodimer
  Labeled with Alexa Fluor 555 via amines
  With an excitation and emission maximum of 555/565 nm, Alexa Fluor 555 can be efficiently excited using a 543 nm He-Ne laser line and detected under standard TRITC/Cy3 filters.
• Applications: Flow Cytometry: Detection of membrane-bound mouse BAFF and human APRIL in combination with fluorescently labelled Ab to IgG1.
• Storage: Stable for at least 6 months after receipt when stored at -20 centigrade. Avoid freeze/thaw cycles.
• Concentration: 1 mg/mL
• Storage Buffer: Contains PBS.
• Reconstitution: Reconstitute with 50 μl of sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.

Gene Information

• Gene Name: TNFRSF17 tumor necrosis factor receptor superfamily, member 17 [ Homo sapiens ]
• Official Symbol: TNFRSF17
• Synonyms: TNFRSF17; tumor necrosis factor receptor superfamily, member 17; BCM; BCMA; CD269; TNFRSF17; tumor necrosis factor receptor superfamily member 17; B-cell maturation factor; B-cell maturation protein
• Gene ID: 608
• mRNA Refseq: NM_001192
• Protein Refseq: NP_001183
• MIM: 109545
• UniProt ID: Q02223