Active Recombinant Human TNFRSF10D, Fc-tagged

• Cat.No.: TNFRSF10D-563H
• Product Overview: The recombinant human DcR2-Fc fusion is expressed as a 382 amino acid protein consisting of Ala56 - Pro209 region of DcR2 (UniProt accession #Q9UBN6) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.

Specification

• Species: Human
• Source: Human Cells
• Tag: Fc
• Protein Length: 56-209 a.a.
• Form: Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier and preservative free)
• Bio-activity: Binds to its ligand human TRAIL and inhibits TRAIL-mediated signaling activity including TRAIL--induced cytotoxicity
• Molecular Mass: Calculated molecular mass (kDa): 42.1; Estimated by SDS-PAGE under reducing condition (kDa): 50-60
• Endotoxin: <0.1 eu per 1 μg of purified recombinant protein determined by the
• Purity: >95% judged by SDS-PAGE under reducing condition
• Storage: The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain [ Homo sapiens ]
• Official Symbol: TNFRSF10D
• Synonyms: TNFRSF10D; tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain; tumor necrosis factor receptor superfamily member 10D; CD264; DcR2; TRAILR4; TRUNDD; TRAIL receptor 4; decoy receptor 2; decoy with truncated death domain; TNF receptor-related receptor for TRAIL; TRAIL receptor with a truncated death domain; TNF-related apoptosis-inducing ligand receptor 4; DCR2; TRAIL-R4
• Gene ID: 8793
• mRNA Refseq: NM_003840
• Protein Refseq: NP_003831
• MIM: 603614
• UniProt ID: Q9UBN6
• Chromosome Location: 8p21
• Pathway: Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Direct p53 effectors, organism-specific biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem
• Function: TRAIL binding; binding; receptor activity; transmembrane signaling receptor activity