Active Recombinant Human TNFRSF10C, Fc-tagged, Biotinylated

• Cat.No.: TNFRSF10C-594H
• Product Overview: The recombinant human DcR1-Fc fusion is expressed as a 438 amino acid protein consisting of Ala26 - Pro235 region of DcR1 (UniProt accession #O14798) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.

Specification

• Species: Human
• Source: Human Cells
• Tag: Fc
• Protein Length: 26-235 a.a.
• Form: Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free). The purified recombinant protein was labeled with Biotin (3-5 Biotin per molecule).
• Bio-activity: Binds to its ligand human TRAIL and inhibits TRAIL-mediated signaling activity including TRAIL-induced cytotoxicity in L-929 mouse fibroblast cells.
• Molecular Mass: Calculated molecular mass (kDa): 47.7; Estimated by SDS-PAGE under reducing condition (kDa): 65-75
• Endotoxin: <0.1 eu per 1 μg of purified recombinant protein determined by the
• Purity: >95% judged by SDS-PAGE under reducing condition
• Storage: The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain [ Homo sapiens ]
• Official Symbol: TNFRSF10C
• Synonyms: TNFRSF10C; tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain; tumor necrosis factor receptor superfamily member 10C; CD263; DcR1; LIT; TRAILR3; TRID; decoy receptor 1; cytotoxic TRAIL receptor-3; lymphocyte inhibitor of TRAIL; decoy TRAIL receptor without death domain; antagonist decoy receptor for TRAIL/Apo-2L; TNF-related apoptosis-inducing ligand receptor 3; DCR1; TRAIL-R3; DCR1-TNFR; MGC149501; MGC149502
• Gene ID: 8794
• mRNA Refseq: NM_003841
• Protein Refseq: NP_003832
• MIM: 603613
• UniProt ID: O14798
• Chromosome Location: 8p22-p21
• Pathway: Apoptosis, organism-specific biosystem; Apoptosis, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Direct p53 effectors, organism-specific biosystem; Influenza A, organism-specific biosystem; Influenza A, conserved biosystem
• Function: TRAIL binding; binding; receptor activity; transmembrane signaling receptor activity