Active Recombinant Human SUMO1

• Cat.No.: SUMO1-558H
• Product Overview: Recombinant Human SUMO1 (Accession # NM_003352) was produced in E. coli-derived.

Specification

• Source: E. coli
• Species: Human
• Form: X mg/ml (X µM) in 50 mM HEPES pH 8.0, 150 mM NaCl, 1mM DTT. Actual protein concentration will vary with specific Lot #
• Bio-activity: Recombinant Human Pro-SUMO1 can be conjugated to substrate proteins via the subsequent actions of an SUMO-activating (E1) enzyme, an SUMO-conjugating (E2) enzyme, and an SUMO ligase (E3). Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human Pro-SUMO1 concentration of 10-50 µM.
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.
• Storage: Avoid repeated freeze-thaw cycles. No activity loss was observed after storage at: In lyophilized state for 1 year (4ºC); After reconstitution under sterile conditions for 3 months (-70ºC).
• Tag: Non

Gene Information

• Gene Name: SUMO1 SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae) [ Homo sapiens ]
• Official Symbol: SUMO1
• Synonyms: SUMO1; SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae); SMT3 suppressor of mif two 3 homolog 1 (yeast) , ubiquitin like 1 (sentrin) , UBL1; small ubiquitin-related modifier 1; GMP1; OFC10; PIC1; SMT3C; SMT3H3; SUMO 1; sentrin; SMT3 homolog 3; GAP modifying protein 1; ubiquitin-like protein UBL1; ubiquitin-like protein SMT3C; ubiquitin-homology domain protein PIC1; DAP1; SMT3; UBL1; SENP2
• Gene ID: 7341
• mRNA Refseq: NM_001005781
• Protein Refseq: NP_001005781
• MIM: 601912
• UniProt ID: P63165
• Chromosome Location: 2q33

Reviews

05/07/2022

Swift protein expression optimization, boosts our research efficiency.

11/30/2021

Accurate protein structural characterization, vital for our studies.

02/03/2018

High-quality protein sequencing, invaluable for our work.

Q&As

How do alterations in SUMO1 expression or conjugation affect cancer development and progression?

Changes in SUMO1 expression or activity can contribute to cancer development, affecting tumor cell behavior and environment.

How does SUMO1 modification affect the stability and function of target proteins?

SUMO1 modification alters target protein stability and function, affecting various cellular processes.

What role does SUMO1 play in regulating gene expression and chromatin organization?

SUMO1 regulates gene expression and chromatin structure, influencing transcriptional activity.

How does SUMO1 influence the DNA damage response and repair processes?

SUMO1 is involved in the DNA damage response, aiding in DNA repair and maintaining genomic integrity.

What is the impact of SUMO1 on cellular stress responses, particularly in neurodegenerative diseases?

SUMO1 impacts cellular stress responses, playing a significant role in neurodegenerative disease mechanisms.

How does SUMO1 contribute to the regulation of cell cycle progression and apoptosis?

SUMO1 modulates cell cycle progression and apoptosis, contributing to cell survival and turnover.

What are the mechanisms by which SUMO1 modulates signal transduction pathways, especially in immune responses?

SUMO1 influences signal transduction, particularly in immune cell signaling and response.