Active Recombinant Human STK17B, GST-tagged

• Cat.No.: STK17B-243H
• Product Overview: Recombinant full-length human DRAK2 (STK17B) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: DRAK2 is a member of the serine/threonine kinase family and is related to death-associated protein kinase that triggers apoptosis. DRAK2 is selectively important for T-cell survival and inhibition of DRAK2 has therapeutic potential for autoimmune disease. T-cell survival depends on a balance of T-cell receptor and co-stimulatory signals and deficiency of DRAK2 can affect autoimmune disease susceptibility without generalized suppression of the immune system.
• Source: Sf9 insect cells using baculovirus
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tis-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: The specific activity of STK17B was determined to be 9.5 nmol /min/mg
• Molecular Mass: ~69 kDa
• Purity: >95% by densitometry
• Applications: Kinase Assay, Western Blot
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μl

Gene Information

• Gene Name: STK17B serine/threonine kinase 17b [ Homo sapiens ]
• Official Symbol: STK17B
• Synonyms: STK17B; serine/threonine kinase 17b; serine/threonine kinase 17b (apoptosis inducing); serine/threonine-protein kinase 17B; death associated protein kinase related 2; DRAK2; death-associated protein kinase-related 2; DAP kinase-related apoptosis-inducing protein kinase 2
• Gene ID: 9262
• mRNA Refseq: NM_004226
• Protein Refseq: NP_004217
• MIM: 604727
• UniProt ID: O94768
• Chromosome Location: 2q33.1
• Function: ATP binding; nucleotide binding; protein serine/threonine kinase activity