Active Recombinant Human RSPO1 Protein (Ser21-Ala263), N-His-SUMO tagged, Animal-free, Carrier-free
| Cat.No. : | RSPO1-132H |
| Product Overview : | Recombinant Human RSPO1 Protein (Ser21-Ala263) with N-His-SUMO tag was expressed in HEK293 and Animal-free as well as Carrier-free. |
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| Description : | R-spondin 1 (RSPO1, Roof plate-specific Spondin 1) is a cysteine-rich secreted glycoprotein that belongs to the R-Spondin family. Structurally, R-spondin 1 harbors an N-terminal signal peptide, two cysteine-rich furin-like (FU1-FU2) domains, a thrombospondin (TSP) domain, and a basic amino acid-rich (BR) C-terminal domain. R-spondin 1 acts as a ligand for the leucine-rich repeat-containing G-protein coupled receptor (LGR) family (LGR4/5/ 6), subsequent clearing negative regulators ZNRF3 /RNF43 from the membrane, leading to the availability of Wnt receptor and activating Wnt/β-catenin signaling. The signal cascade is essential for regulating stem cell proliferation, embryonic development, and tissue homeostasis. |
| Source : | HEK293 cell |
| Species : | Human |
| Tag : | N-His-SUMO |
| Form : | Liquid |
| Bio-activity : | R-Spondin-1 enhances BMP-2-mediated differentiation of MC3T3-E1 cells. The ED50 for this effect is 1-3 μg/mL. |
| Molecular Mass : | The protein has a calculated MW of 46.8 kDa. The protein migrates as 62-68 kDa under reducing condition (SDS-PAGE analysis). |
| Protein length : | Ser21-Ala263 |
| Endotoxin : | < 1 EU/μg of the protein by the LAL method. |
| Purity : | >95% as determined by SDS-PAGE analysis. |
| Storage : | This product is stable after storage at: -80 centigrade for long-term storage under sterile conditions. Avoid repeated free-thaw cycles. |
| Storage Buffer : | Phosphate buffered saline, pH 7.4. |
| Shipping : | The product is shipped with polar packs. Upon receipt, store it immediately at -20 centigrade or lower for long term storage. |
| Gene Name | RSPO1 R-spondin 1 [ Homo sapiens (human) ] |
| Official Symbol | RSPO1 |
| Synonyms | RSPO1; R-spondin 1; R spondin homolog (Xenopus laevis); R-spondin-1; FLJ40906; RSPONDIN; R-spondin homolog; roof plate-specific spondin-1; RSPO; CRISTIN3; RP11-566C13.1; |
| Gene ID | 284654 |
| mRNA Refseq | NM_001038633 |
| Protein Refseq | NP_001033722 |
| MIM | 609595 |
| UniProt ID | Q2MKA7 |
Not For Human Consumption!
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