Active Recombinant Human PPIB
| Cat.No. : | PPIB-8314H |
| Product Overview : | Cyclophilin B Human Recombinant produced in E.coli is a single, non-glycosylated,polypeptide chain containing 192 amino acids (26-216) and having a molecular mass of 21.2 kDa. PPIB is purified by chromatographic techniques. |
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| Description : | The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. |
| Source : | E.coli |
| Species : | Human |
| Form : | 1 mg/ml solution containing 20 mM Tris 8.0, 20 mM NaCl, 0.5mM DTT and 10% glycerol. |
| Bio-activity : | Specific activity is 170 nmoles/min/ug, and is defined as the amount of enzyme that cleave 1umole of suc-AAFP-pNA per minute at 1C in Tris-Hcl pH8.0 using chymotrypsin. |
| AA Sequence : | MLLPGPSAAD EKKKGPKVTV KVYFDLRIGD EDVGRVIFGL FGKTVPKTVD NFVALATGEKGFGYKNSKFH RVIKDFMIQG GDFTRGDGTG GKSIYGERFP DENFKLKHYG PGWVSMANAGKDTNGSQFFI TTVKTAWLDG KHVVFGKVLE GMEVVRKVES TKTDSRDKPL KDVIIADCGK IEVEKPFAIA KE. |
| Purity : | Greater than 95.0% as determined by RP-HPLC and analysis by SDS-PAGE |
| Notes : | For research use only. |
| Storage : | PPIase Human Recombinant although stable at 4 ℃ for weeks, should be stored desiccated below -18 ℃. Please prevent freeze/thaw cycles. |
| Tag : | Non |
| Protein length : | 26-216 a.a. |
| Gene Name | PPIB peptidylprolyl isomerase B (cyclophilin B) [ Homo sapiens ] |
| Official Symbol | PPIB |
| Synonyms | PPIB; peptidylprolyl isomerase B (cyclophilin B); peptidyl-prolyl cis-trans isomerase B; CYPB; OI9; |
| Gene ID | 5479 |
| mRNA Refseq | NM_000942 |
| Protein Refseq | NP_000933 |
| MIM | 123841 |
| UniProt ID | P23284 |
| Chromosome Location | 15q21-q22 |
| Pathway | Syndecan-1-mediated signaling events, organism-specific biosystem; |
| Function | isomerase activity; peptide binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; unfolded protein binding; |
Not For Human Consumption!
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