Active Recombinant Human PCSK2, His-tagged

• Cat.No.: PCSK2-88H
• Product Overview: Recombinant Human PCSK2 (Gly110-Asn638) fused with 6­His tag at C­terminal, was expressed in CHO Cells.

Specification

• Description: This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in hormone biosynthesis by processing a variety of prohormones including proinsulin, proopiomelanocortin and proluteinizing-hormone-releasing hormone. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Source: CHO Cells
• Species: Human
• Tag: His
• Predicted N Terminal: Gly110
• Form: Supplied as a 0.2 µm filtered solution in Tris, NaCl and CaCl2.
• Bio-activity: Measured by its ability to cleave the fluorogenic peptide substrate pERTKR-AMC. The specific activity is >60 pmol/min/µg, as measured under the described conditions.
• Molecular Mass: 59 kDa
• Endotoxin: < 1.0 EU per 1 μg of the protein by the LAL method.
• Purity: >90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening.
• Protein length: 110-638 a.a.

Gene Information

• Gene Name: PCSK2 proprotein convertase subtilisin/kexin type 2 [ Homo sapiens (human) ]
• Official Symbol: PCSK2
• Synonyms: PCSK2; PC2; NEC2; SPC2; NEC 2; NEC-2; proprotein convertase subtilisin/kexin type 2; neuroendocrine convertase 2; prohormone convertase 2; KEX2-like endoprotease 2; EC 3.4.21.94
• Gene ID: 5126
• mRNA Refseq: NM_002594
• Protein Refseq: NP_002585
• MIM: 162151
• UniProt ID: P16519
• Chromosome Location: 20p11.2
• Pathway: Insulin Processing; Metabolism of proteins; Peptide hormone metabolism
• Function: protein binding; protein complex binding; serine-type endopeptidase activity