Active Recombinant Human PARP3, HA-tagged
Cat.No. : | PARP3-454H |
Product Overview : | Human full-length PARP-3 [ARTD3] is fused to a HA-tag and a His-tag. |
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Species : | Human |
Source : | Sf21 Cells |
Tag : | HA |
Description : | PARP-3 [ARTD3] is involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing. |
Form : | Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 50mM imidazole, 0.2% NP-40 and 10% glycerol. |
Bio-activity : | ≥10U/mg protein (only monoADP-ribosyl transferase activity). |
Purity : | ≥98% (SDS-PAGE) |
Stability : | Stable for at least 6 months after receipt when stored at -80°C. |
Storage : | Short Term Storage: -20°C; Long Term Storage: -80°C. After opening, prepare aliquots and store at -80°C. Avoid freeze/thaw cycles. |
Concentration : | Lot dependent (0.2-1mg/ml) |
Gene Name | PARP3 poly (ADP-ribose) polymerase family, member 3 [ Homo sapiens ] |
Official Symbol | PARP3 |
Synonyms | PARP3; poly (ADP-ribose) polymerase family, member 3; ADP ribosyltransferase (NAD+; poly (ADP ribose) polymerase) like 3 , ADPRTL3; poly [ADP-ribose] polymerase 3; ADPRT3; hPARP 3; IRT1; NAD+ ADP ribosyltransferase 3; pADPRT 3; poly(ADP ribose) polymerase 3; poly(ADP ribose) synthetase 3; ADPRT-3; poly[ADP-ribose] synthase 3; NAD+ ADP-ribosyltransferase 3; poly(ADP-ribose) synthetase-3; poly[ADP-ribose] synthetase 3; NAD(+) ADP-ribosyltransferase 3; ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 2; poly (ADP-ribose) polymerase)-like 3; ADPRTL2; ADPRTL3; PADPRT-3; |
Gene ID | 10039 |
mRNA Refseq | NM_001003931 |
Protein Refseq | NP_001003931 |
MIM | 607726 |
UniProt ID | Q9Y6F1 |
Chromosome Location | 3p22.2-p21.1 |
Pathway | BER complex, organism-specific biosystem; BER complex, conserved biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; |
Function | NAD+ ADP-ribosyltransferase activity; catalytic activity; transferase activity, transferring glycosyl groups; |
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Not For Human Consumption!
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