Active Recombinant Human/Mouse/Rat INHBA Protein (Gly311-Ser426), GMP Grade

Cat.No. : INHBA-09HG
Product Overview : GMP recombinant human/Mouse/Rat Activin A protein (Gly311-Ser426) without tag was expressed in Chinese Hamster Ovary cell line and manufactured and tested under cGMP guidelines.
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Species : Human/Mouse/Rat
Source : CHO
Protein Length : Gly311-Ser426
Description : This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. The encoded protein also plays a role in eye, tooth and testis development. Elevated expression of this gene may be associated with cancer cachexia in human patients.
Form : Disulfide-linked homodimer
Bio-activity : Measured by its ability to induce hemoglobin expression in K562 human chronic myelogenous leukemia cells. The ED50 for this effect is 0.2-1.2 ng/mL.
The specific activity of Recombinant Human/Mouse/Rat Activin A is >1000 units/mg, which is calibrated against the human Activin A WHO reference standard.
Molecular Mass : Predicted Molecular Mass: 13 kDa (monomer)
SDS-PAGE: 14 kDa, reducing conditions; 24 kDa, non-reducing conditions
N-terminal Sequence Analysis : Gly311-Leu-Glu-(Cys)-Asp-Gly-Lys-Val-Asn-Ile
Endotoxin : <0.10 EU/ μg of the protein by the LAL method.
Purity : >97%, by SDS-PAGE with silver staining.
Storage : Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
A minimum of 12 months when stored at ≤ -20 centigrade as supplied. Refer to lot specific COA for the Use by Date.
1 month, 2 to 8 centigrade under sterile conditions after reconstitution.
3 months, ≤ -20 centigrade under sterile conditions after reconstitution.
Storage Buffer : Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA.
Reconstitution : Reconstitute at 100-500 μg/mL in sterile 4 mM HCl.
Shipping : The product is shipped with polar packs.
Gene Name INHBA inhibin, beta A [ Homo sapiens ]
Official Symbol INHBA
Synonyms INHBA; inhibin, beta A; inhibin, beta A (activin A, activin AB alpha polypeptide); inhibin beta A chain; Inhibin, beta-1; activin beta-A chain; FSH-releasing protein; erythroid differentiation factor; erythroid differentiation protein; follicle-stimulating hormone-releasing protein; EDF; FRP;
Gene ID 3624
mRNA Refseq NM_002192
Protein Refseq NP_002183
MIM 147290
UniProt ID P08476

Not For Human Consumption!

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