Active Recombinant Human MET Protein, GST-tagged

• Cat.No.: MET-35H
• Product Overview: Recombinant human MET (Del Ex14) or (Del 963-1009) (956-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Description: This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers.
• Source: Insect cell
• Species: Human
• Tag: GST
• Bio-activity: 38 nmol/min/mg
• Molecular Mass: 71 kDa
• Purity: > 85 %
• Stability: 0ne year at -70 centigrade from date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μL
• Storage Buffer: 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25 % glycerol
• Shipping: Dry ice
• Protein length: 956-end a.a.

Gene Information

• Gene Name: MET MET proto-oncogene, receptor tyrosine kinase [ Homo sapiens (human) ]
• Official Symbol: MET
• Synonyms: MET; MET proto-oncogene, receptor tyrosine kinase; HGFR; AUTS9; RCCP2; c-Met; DFNB97; hepatocyte growth factor receptor; HGF receptor; HGF/SF receptor; SF receptor; proto-oncogene c-Met; scatter factor receptor; tyrosine-protein kinase Met; EC 2.7.10.1
• Gene ID: 4233
• mRNA Refseq: NM_000245
• Protein Refseq: NP_000236
• MIM: 164860
• UniProt ID: P08581