Active Recombinant Human MAPK3 Protein

• Cat.No.: MAPK3-307H
• Product Overview: Recombinant full-length, tag-free human ERK1 was expressed in E.coli cells and activated by active MEK1 in vitro.

Specification

• Species: Human
• Source: E.coli
• Description: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described.
• Bio-activity: 380 nmol/min/mg
• Molecular Mass: ~44 kDa
• Purity: >80%
• Stability: One year at -70 centigrade from date of shipment.
• Storage: Store product at –70 centigrade. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Concentration: 0.1 μg/μL
• Storage Buffer: 25 mM MOPS, pH 7.5, 300 mM NaCl, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 0.25% glycerol.
• Shipping: Dry ice.

Gene Information

• Gene Name: MAPK3 mitogen-activated protein kinase 3 [ Homo sapiens (human) ]
• Official Symbol: MAPK3
• Synonyms: MAPK3; mitogen-activated protein kinase 3; ERK1; ERT2; ERK-1; PRKM3; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK; mitogen-activated protein kinase 3; MAPK 1; extracellular signal-regulated kinase 1; extracellular signal-related kinase 1; insulin-stimulated MAP2 kinase; microtubule-associated protein 2 kinase; EC 2.7.11.24
• Gene ID: 5595
• mRNA Refseq: NM_002746
• Protein Refseq: NP_002737
• MIM: 601795
• UniProt ID: P27361