Active Recombinant Human KITLG Protein
Cat.No. : | KITLG-961H |
Product Overview : | Recombinant Human KITLG(Glu26-Ala189), transcript variant b, was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
- Download
Species : | Human |
Source : | E.coli |
Tag : | Non |
Protein Length : | 26-189 a.a. |
Description : | Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. |
Form : | 1 x PBS |
Bio-activity : | The ED50 is 3 -12 ng/ml, corresponding to a specific activity of 0.8 - 3.3 x 10^5 units/mg, determined by TF-1 cell proliferation induced in a dose dependent manner. |
Molecular Mass : | 18.6 kDa |
Endotoxin : | Less than 0.01 ng per µg protein as determined by the LAL method. |
Purity : | >98%, as determined by Coomassie stained SDS-PAGE. |
Concentration : | Protein formulated and vialed at >50 ug/mL in specified buffer |
Gene Name | KITLG KIT ligand [ Homo sapiens ] |
Official Symbol | KITLG |
Synonyms | KITLG; KIT ligand; MGF; kit ligand; familial progressive hyperpigmentation 2; FPH2; Kitl; KL 1; mast cell growth factor; SCF; SF; steel factor; stem cell factor; c-Kit ligand; KL-1; SHEP7; kit-ligand; DKFZp686F2250; |
Gene ID | 4254 |
mRNA Refseq | NM_000899 |
Protein Refseq | NP_000890 |
MIM | 184745 |
UniProt ID | P21583 |
◆ Recombinant Proteins | ||
Kitl-3698M | Active Recombinant Mouse Kitl Protein | +Inquiry |
KITLG-057K | Active Recombinant Human KITLG Protein (165 aa) | +Inquiry |
KITLG-2921R | Recombinant Rat KITLG Protein, His (Fc)-Avi-tagged | +Inquiry |
KITLG-306H | Active Recombinant Human KIT Ligand | +Inquiry |
KITLG-3748C | Recombinant Chicken KITLG | +Inquiry |
◆ Cell & Tissue Lysates | ||
KITLG-583MCL | Recombinant Mouse KITLG cell lysate | +Inquiry |
KITLG-571HCL | Recombinant Human KITLG cell lysate | +Inquiry |
Not For Human Consumption!
Inquiry
- Reviews
- Q&As
Ask a Question for All KITLG Products
Required fields are marked with *
My Review for All KITLG Products
Required fields are marked with *
0
Inquiry Basket