Active Recombinant Human KITLG Protein

Cat.No. : KITLG-961H
Product Overview : Recombinant Human KITLG(Glu26-Ala189), transcript variant b, was expressed in E. coli.
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Species : Human
Source : E.coli
Tag : Non
Protein Length : 26-189 a.a.
Description : Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Form : 1 x PBS
Bio-activity : The ED50 is 3 -12 ng/ml, corresponding to a specific activity of 0.8 - 3.3 x 10^5 units/mg, determined by TF-1 cell proliferation induced in a dose dependent manner.
Molecular Mass : 18.6 kDa
Endotoxin : Less than 0.01 ng per µg protein as determined by the LAL method.
Purity : >98%, as determined by Coomassie stained SDS-PAGE.
Concentration : Protein formulated and vialed at >50 ug/mL in specified buffer
Gene Name KITLG KIT ligand [ Homo sapiens ]
Official Symbol KITLG
Synonyms KITLG; KIT ligand; MGF; kit ligand; familial progressive hyperpigmentation 2; FPH2; Kitl; KL 1; mast cell growth factor; SCF; SF; steel factor; stem cell factor; c-Kit ligand; KL-1; SHEP7; kit-ligand; DKFZp686F2250;
Gene ID 4254
mRNA Refseq NM_000899
Protein Refseq NP_000890
MIM 184745
UniProt ID P21583

Not For Human Consumption!

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