Active Recombinant Human KAT5, GST-tagged

• Cat.No.: KAT5-1350H
• Product Overview: Full-length recombinant human KAT5 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: Full length
• Description: KAT5 or K (lysine) acetyltransferase 5 is a signaling protein that belongs to the MYST family of histone acetyl transferases (HATs). KAT5 was originally isolated as an HIV-1 TAT-interactive protein that plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. KAT5 protein is a histone acetylase that is involved in DNA repair and apoptosis and plays an important role in signal transduction. KAT5 acts as a cofactor of TAT that is involved in the regulation of HIV gene expression. KAT5 is also a co-regulator of transcription factors that either promote or suppress tumorigenesis.
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 30 nmol/min/mg
• Molecular Mass: ~88 kDa
• Purity: >90%
• Applications: Acetyltransferase Assay
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.1 μg/μl
• Publications:
  Targeted systematic evolution of an RNA platform neutralizing DNMT1 function and controlling DNA methylation (2023)

Gene Information

• Gene Name: KAT5 K(lysine) acetyltransferase 5 [ Homo sapiens ]
• Official Symbol: KAT5
• Synonyms: KAT5; K(lysine) acetyltransferase 5; HIV 1 Tat interactive protein, 60kDa , HTATIP; histone acetyltransferase KAT5; cPLA2; ESA1; HTATIP1; K acetyltransferase 5; PLIP; Tat interacting protein; 60kDa; TIP60; K-acetyltransferase 5; cPLA2 interacting protein; lysine acetyltransferase 5; cPLA(2)-interacting protein; 60 kDa Tat-interactive protein; Tat interacting protein, 60kDa; histone acetyltransferase HTATIP; HIV-1 Tat interactive protein, 60kDa; TIP; HTATIP
• Gene ID: 10524
• mRNA Refseq: NM_001206833
• Protein Refseq: NP_001193762
• MIM: 601409
• UniProt ID: Q92993
• Chromosome Location: 11q13
• Pathway: ATF-2 transcription factor network, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; C-MYC pathway, organism-specific biosystem; HTLV-I infection, organism-specific biosystem; HTLV-I infection, conserved biosystem; IL-9 Signaling Pathway, organism-specific biosystem; Regulation of Androgen receptor activity, organism-specific biosystem
• Function: androgen receptor binding; contributes_to histone acetyltransferase activity; metal ion binding; protein binding; repressing transcription factor binding; transcription coactivator activity; transcription coactivator activity; transferase activity, transferring acyl groups other than amino-acyl groups