Active Recombinant Human ITGA6

• Cat.No.: ITGA6-4110H
• Product Overview: Recombinant Human ITGA6 was expressed in CHO Cells.

Specification

• Species: Human
• Source: CHO
• Tag: Non
• Description: The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
• Predicted N Terminal: Phe24 ( alpha 6) & Asn28 ( beta 4)
• Formulation: Lyophilized from a 0.2 µm filtered solution in PBS.
• Bio-activity: Measured by its binding ability in a functional ELISA. When mouse Laminin I is coated at 10 µg/mL, rhIntegrin alpha 6 beta 4 binds with an apparent KD < 5 nM.
• Molecular Mass: 104 kDa ( alpha 6) & 84.8 kDa ( beta 4)
• Purity: >95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
• Storage: 12 months from date of receipt, ­20 to ­70 °C as supplied. Avoid repeated freeze­thaw cycles.
• Reconstitution: Reconstitute at 200 µg/mL in sterile PBS.
• Shipping: The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Gene Information

• Gene Name: ITGA6 integrin, alpha 6 [ Homo sapiens (human) ]
• Official Symbol: ITGA6
• Synonyms: ITGA6; integrin, alpha 6; CD49f; VLA-6; ITGA6B; integrin alpha-6; integrin alpha6B; CD49 antigen-like family member F
• Gene ID: 3655
• mRNA Refseq: NM_000210
• Protein Refseq: NP_000201
• MIM: 147556
• UniProt ID: P23229
• Chromosome Location: 2q31.1
• Pathway: Alpha6-Beta4 Integrin Signaling Pathway; Arf6 trafficking events; Arrhythmogenic right ventricular cardiomyopathy; Assembly of collagen fibrils and other multimeric structures
• Function: metal ion binding; protein binding