Active Recombinant Human Interleukin 17 Receptor C, HIgG1 Fc-tagged, mutant

• Cat.No.: IL17RC-641H
• Product Overview: The extracellular domain of human IL-17RC (NP_116121.2)(Leu21-Ala454) is fused to the N-terminus of the Fc region of a mutant human IgG1was expressed in CHO cell.

Specification

• Species: Human
• Source: CHO
• Tag: Fc
• Protein Length: 21-454 a.a.
• Description: This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to bind rhIL-17 in a functional ELISA.
• Molecular Mass: 74KDa (monomer)
• AA Sequence: Leu21-Ala454
• Endotoxin: <0.06 eu/μg="" as="" determined="" by="" lal="">
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: IL17RC interleukin 17 receptor C [ Homo sapiens ]
• Official Symbol: IL17RC
• Synonyms: IL17RC; interleukin 17 receptor C; interleukin-17 receptor C; IL17 RL; IL-17RL; IL17Rhom; zcytoR14; IL17F receptor; IL-17 receptor C; interleukin-17 receptor homolog; interleukin-17 receptor-like protein; IL17RL; IL17-RL; FLJ95963; FLJ96005; MGC10763
• Gene ID: 84818
• mRNA Refseq: NM_001203263
• Protein Refseq: NP_001190192
• MIM: 610925
• UniProt ID: Q8NAC3
• Chromosome Location: 3p25.3
• Function: receptor activity