Active Recombinant Human INHBA protein, His-tagged

• Cat.No.: INHBA-268H
• Product Overview: Recombinant Human Activin A fused with His tag was expressed in Nicotiana benthamiana.

Specification

• Species: Human
• Source: Nicotiana Benthamiana
• Tag: His
• Description: Activin A is a TGF beta family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in post-menopausal woman have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF beta antagonist, Follistatin.
• Form: Lyophilized from 50mM Tris HCl at pH 7.4.
• Bio-activity: ED50 5 ng/ml.
• Molecular Mass: 27,4 kDa
• AA Sequence: HHHHHHGLECDGKVNICCKKQFFVSFKDIGWNDWIIAPSGYHANYCE GECPSHIAGTSGSSLSFHSTVINHYRMRGHSPFANLKSCCVPTKLRPM SMLYYDDGQNIIKKDIQNMIVEECGCS
• Endotoxin: <0.04 EU/ug protein (LAL method)
• Purity: > 97% by SDS - PAGE gel. Sequential chromatography (FPLC)
• Notes: Small volumes of Activin A (active) (His tag) recombinant protein may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
• Storage: Aliquot and store at -20 centigrade. Avoid repeated freeze/thaw Cycles
• Concentration: 50 ng/ul (lot specific)

Gene Information

• Gene Name: INHBA inhibin, beta A [ Homo sapiens ]
• Official Symbol: INHBA
• Synonyms: INHBA; inhibin, beta A; inhibin, beta A (activin A, activin AB alpha polypeptide); inhibin beta A chain; Inhibin, beta-1; activin beta-A chain; FSH-releasing protein; erythroid differentiation factor; erythroid differentiation protein; follicle-stimulating hormone-releasing protein; EDF; FRP
• Gene ID: 3624
• mRNA Refseq: NM_002192
• Protein Refseq: NP_002183
• MIM: 147290
• UniProt ID: P08476
• Chromosome Location: 7p15-p13
• Pathway: ALK1 signaling events, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Glycoprotein hormones, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem; Peptide hormone biosynthesis, organism-specific biosystem
• Function: cytokine activity; follistatin binding; growth factor activity; hormone activity; identical protein binding; protein binding; protein heterodimerization activity; type II activin receptor binding