Active Recombinant Human IL2RB, MIgG2a Fc-tagged
| Cat.No. : | IL2RB-700H |
| Product Overview : | The extracellular domain of human IL-2RB(AAH25691.1)(Ala27-Asp239) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell. |
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| Description : | IL2RB (interleukin 2 receptor, beta) is a protein-coding gene. Diseases associated with IL2RB include occipital neuralgia, and granulomatous orchitis, and among its related super-pathways are STAT3 Pathway and IL2-mediated signaling events. GO annotations related to this gene include interleukin-2 receptor activity and interleukin-2 binding. |
| Source : | CHO cell |
| Species : | Human |
| Tag : | MIgG2a Fc-tagged |
| Form : | Lyophilized from 0.2μm-filtered solution in PBS. |
| Bio-activity : | Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2. |
| Molecular Mass : | 51KDa (monomer) |
| AA Sequence : | Ala27-Asp239 |
| Endotoxin : | <0.06 eu/μg="" as="" determined="" by="" lal="" test.=""> |
| Purity : | >98%, by SDS-PAGE under reducing conditions. |
| Stability : | Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C. |
| Reconstitution : | Reconstitute at 100μg/ml in sterile PBS. |
| Warning : | Avoid freeze/thaw cycles. |
| Protein length : | 27-239 a.a. |
| Gene Name | IL2RB interleukin 2 receptor, beta [ Homo sapiens ] |
| Official Symbol | IL2RB |
| Synonyms | IL2RB; interleukin 2 receptor, beta; IL15RB, interleukin 15 receptor, beta; interleukin-2 receptor subunit beta; CD122; p75; IL-2RB; CD122 antigen; IL-2R subunit beta; IL-2 receptor subunit beta; interleukin 15 receptor, beta; high affinity IL-2 receptor beta subunit; high affinity IL-2 receptor subunit beta; IL15RB; P70-75; |
| Gene ID | 3560 |
| mRNA Refseq | NM_000878 |
| Protein Refseq | NP_000869 |
| MIM | 146710 |
| UniProt ID | P14784 |
| Chromosome Location | 22q13 |
| Pathway | Cytokine Signaling in Immune system, organism-specific biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Downstream signaling in naive CD8+ T cells, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; HTLV-I infection, organism-specific biosystem; |
| Function | interleukin-2 binding; interleukin-2 receptor activity; contributes_to interleukin-2 receptor activity; receptor activity; |
Not For Human Consumption!
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