Active Recombinant Human IL13

• Cat.No.: IL13-328H
• Product Overview: Human IL13 (P35225, 19 a.a.-132 a.a.) partial recombinant protein expressed in Escherichia coli.

Specification

• Species: Human
• Source: Human
• Tag: Non
• Description: Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene. IL-13 is cytokine secreted by many cell types, but especially T helper type 2 (Th2) cells, that is an important mediator of allergic inflammation and disease. In addition to effects on immune cells that are similar to those of the closely related cytokine IL-4, IL-13 is more importantly implicated as a central mediator of the physiologic changes induced by allergic inflammation in many tissues. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rμ) and at least one of two known IL-13-specific binding chains.
• Sequence: SP GPVPPSTALR ELIEELVNIT QNQKAPLCNG SMVWSINLTA GMYCAALESL INVSGCSAIE KTQRMLSGFC PHKVSAGQFS SLHVRDTKIE VAQFVKDLLL HLKKLFREGR FN
• Theoretical MW (kDa): 13
• Form: Lyophilized
• Preparation Method: Escherichia coli expression system
• Purity: > 95% by SDS-PAGE and HPLC
• Endotoxin Level: < 0.1 ng/ug (1 EU/ug)
• Activity: The ED50 was determined by the dose-dependent proliferation of TF-1 cells was μ2.0 ng/mL, corresponding to a specific activity of μ 1 x 106units/mg.
• Application: SDS-PAGE
• Storage Buffer: Lyophilized from PBS, pH 7.2
• Storage: Store at -20°C on dry atmosphere for 2 years. After reconstitution with deionized water, store at 4°C for 1 month or store at -20°C for 6 months. Aliquot to avoid repeated freezing and thawing.
• Unitprot ID: P35225
• Pathways: Asthma; Cytokine-cytokine receptor interaction; Fc epsilon RI signaling pathway; Jak-STAT signaling pathway

Gene Information

• Gene Name: IL13 interleukin 13 [ Homo sapiens ]
• Official Symbol: IL13
• Synonyms: IL13; interleukin 13; ALRH; BHR1; P600; IL-13; MGC116786; MGC116788; MGC116789; Interleukin-13; NC30
• Gene ID: 3596
• mRNA Refseq: NM_002188
• Protein Refseq: NP_002179
• MIM: 147683
• Chromosome Location: 5q31
• Function: cytokine activity; interleukin-13 receptor binding; protein binding