Active Recombinant Human IGFBP2 Protein, His-tagged

• Cat.No.: IGFBP2-185I
• Product Overview: Recombinant Human IGFBP2 Protein with His tag was expressed in HEK 293.

Specification

• Species: Human
• Source: HEK293
• Tag: His
• Description: IGF-BP-2,also known as Insulin-like growth factor-binding protein 2, IBP-2 and BP-2, is a cysteine-rich secreted protein belonging to the IGF-binding protein superfamily. It is expressed by the central nervous system, bone cells and reproductive tissues. IGF-BP-2 binds to both IGF-I and IGF-II, with a much higher binding affinity to IGF-II than IGF-I. IGF-BP-2 has been shown to inhibitand stimulate the growth promoting effects of IGFs, thus serving as a regulator for IGF distribution, function and activity.
• Form: Sterile Filtered White lyophilized (freeze-dried) powder.
• Bio-activity: ED50 < 2 μg/mL, measured in a bioassay using FDC-P1 cells in the presence of 15 ng/mL human IGF-II.
• Molecular Mass: 6-20 kDa, observed by reducing SDS-PAGE.
• AA Sequence: FRCPPCTPERLAACGPPPVAPPAAVAAVAGGARMPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGSELPLQALVMGEGTCEKRRDAEYGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAGRKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQEARGVHTQRMQHHHHHH
• Endotoxin: < 0.2 EU/μg, determined by LAL method.
• Purity: > 95% as analyzed by SDS-PAGE.
• Storage: Lyophilized recombinant human IGF-BP-2, Hisremains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, human IGF-BP-2, His should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade.
• Storage Buffer: Lyophilized after extensive dialysis against PBS.
• Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Gene Information

• Gene Name: IGFBP2 insulin-like growth factor binding protein 2, 36kDa [ Homo sapiens ]
• Official Symbol: IGFBP2
• Synonyms: IGFBP2; insulin-like growth factor binding protein 2, 36kDa; IBP2, insulin like growth factor binding protein 2 (36kD); insulin-like growth factor-binding protein 2; IBP-2; IGFBP-2; IGF-binding protein 2; IBP2; IGF-BP53
• Gene ID: 3485
• mRNA Refseq: NM_000597
• Protein Refseq: NP_000588
• MIM: 146731
• UniProt ID: P18065