Active Recombinant Human IGF2R, His-tagged

Cat. No. :	IGF2R-611H
Description :	The protein encoded by this gene is a receptor for both, insulin-like growth factor 2 (IGF2) and mannose 6-phosphate (M6P). The IGF2 and M6P binding sites are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of IGF2. While the mouse Igf2r gene shows exclusive expression from the maternal allele, imprinting of the human IGF2R gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele.
Source :	Mammalian cells
Molecular Mass :	The predicted molecular mass is 67 kDa. The apparent molecular mass of this protein is approximately 80-83 kDa in SDS-PAGE under reducing conditions.
Predicted N terminal :	Ser1510
Formulation :	Lyophilized from a 0.2 μm filtered solution in PBS.
Purity :	>90% as determined by SDSPAGE
Activity :	Measured by its binding ability in a functional ELISA. Immobilized rhIGFII R at 2 µg/mL (100 µL/well) can bind rhIGFII with a linear range of 2100 ng/mL.
EndotoxinLevel :	<1.0 EU per 1 μg of the protein by the LAL method.
Storage :	12 months from date of receipt, 20 to 70 °C as supplied. Avoid repeated freezethaw cycles.
OfficialSymbol :	IGF2R

Gene Name	IGF2R insulin-like growth factor 2 receptor [ Homo sapiens ]
Synonyms	IGF2R; insulin-like growth factor 2 receptor; cation-independent mannose-6-phosphate receptor; cation independent mannose 6 phosphate receptor; CD222; CIMPR; M6PR; MPR1; MPRI
Gene ID	3482
mRNA Refseq	NM_000876
Protein Refseq	NP_000867
MIM	147280
UniProt ID	P11717
Chromosome Location	6q26
Pathway	Clathrin derived vesicle budding; Golgi Associated Vesicle Biogenesis; Lysosome; Membrane Trafficking
Function	glycoprotein binding; insulin-like growth factor binding; insulin-like growth factor-activated receptor activity; mannose binding; phosphoprotein binding