Active Recombinant Human IGF2R, Fc-tagged

• Cat.No.: IGF2R-626H
• Product Overview: The recombinant human IGF2R-Fc is expressed as a 714 amino acid protein consisting of Met1508 - Leu1992 region of IGF2R (UniProt #P11717, repeat #11-13) and a C-terminal Fc fusion from human IgG1, which exists as a dimer under non-reducing condition.

Specification

• Source: Human cells
• Species: Human
• Tag: Fc
• Form: Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier free & preservative free).
• Bio-activity: Binds to its ligand IGF2 and inhibits IGF2-mediated signaling activity.
• Molecular Mass: Calculated molecular mass 79.2 kDa; estimated by SDS-PAGE under reducing condition 85-90 kDa probably due to glycosylation
• Endotoxin: <0.1 eu="" per="" 1="" μg="" of="" purified="" recombinant="" protein="" determined="" by="" the="" lal="">
• Purity: >95% judged by SDS-PAGE under reducing condition
• Storage: The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.
• Protein length: 1508-1992 a.a.

Gene Information

• Gene Name: IGF2R insulin-like growth factor 2 receptor [ Homo sapiens ]
• Official Symbol: IGF2R
• Synonyms: IGF2R; insulin-like growth factor 2 receptor; cation-independent mannose-6-phosphate receptor; cation independent mannose 6 phosphate receptor; CD222; CIMPR; M6P R; MPR1; MPRI; M6PR; CI-MPR; MPR 300; M6P/IGF2R; IGF-II receptor; M6P/IGF2 receptor; CI Man-6-P receptor; 300 kDa mannose 6-phosphate receptor; insulin-like growth factor II receptor; cation-independent mannose-6 phosphate receptor; M6P-R
• Gene ID: 3482
• mRNA Refseq: NM_000876
• Protein Refseq: NP_000867
• MIM: 147280
• UniProt ID: P11717
• Chromosome Location: 6q25-q27
• Pathway: Clathrin derived vesicle budding, organism-specific biosystem; Golgi Associated Vesicle Biogenesis, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Membrane Trafficking, organism-specific biosystem; trans-Golgi Network Vesicle Budding, organism-specific biosystem
• Function: glycoprotein binding; insulin-like growth factor binding; insulin-like growth factor-activated receptor activity; mannose binding; phosphoprotein binding; protein binding; receptor activity; transporter activity