Active Recombinant Human Histone Deacetylase 4, GST-tagged

Cat. No. :	HDAC4-395H
Description :	Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
Source :	HDAC4 was cloned from human brain cDNA and expressed in insect cells using a baculoviral expression system.
Purity :	Purified, active enzyme.
Purification Procedure :	Glutathione Column
Activity :	1000 units per vial. 1 unit is defined as the amount of enzyme that will convert 1picomole per minute per ug of protein at pH8 at 30°C.
Stability/Shelf-life :	>6 months from date of shipment
Buffer Composition :	25mM Tris pH8, 120mM NaCl, 0.05% Tween-20 & 40% Glycerol
Storage :	–80°C
Full Length :	Full L.

Gene Name	HDAC4 histone deacetylase 4 [ Homo sapiens ]
Synonyms	HDAC4; HA6116; HD4; HDAC-A; HDACA; KIAA0288; histone deacetylase 4; histone deacetylase A; EC 3.5.1.98.
Gene ID	9759
mRNA Refseq	NM_006037
Protein Refseq	NP_006028
MIM	605314
UniProt ID	P56524
Chromosome Location	2q37.3
Pathway	Gene Expression
Function	DNA binding; histone deacetylase activity; hydrolase activity; A; transcription repressor activity