Active Recombinant Human GDF3

• Cat.No.: GDF3-02H
• Product Overview: Recombinant human GDF-3 is a 26.0 kDa non-disulfide-linked homodimer containing two 114 amino acid polypeptide chains. Manufactured using all non-animal reagents.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: GDF-3 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Unlike most TGF-β family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia which characterizes Type 2 diabetes.
• Bio-activity: Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 100-150 ng/ml.
• AA Sequence: AAIPVPKLSC KNLCHRHQLF INFRDLGWHK WIIAPKGFMA NYCHGECPFS LTISLNSSNY AFMQALMHAV DPEIPQAVCI PTKLSPISML YQDNNDNVIL RHYEDMVVDE CGCG
• Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.
• Storage: Store at -20°C. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: GDF3 growth differentiation factor 3 [ Homo sapiens ]
• Official Symbol: GDF3
• Synonyms: GDF3; growth differentiation factor 3; growth/differentiation factor 3; GDF-3; KFS3; MCOP7; MCOPCB6
• Gene ID: 9573
• mRNA Refseq: NM_020634
• Protein Refseq: NP_065685
• MIM: 606522
• UniProt ID: Q9NR23
• Chromosome Location: 12p13.1
• Function: cytokine activity; growth factor activity