Active Recombinant Human FGF8 Protein

• Cat.No.: FGF8-041H
• Product Overview: The mature recombinant human FGF-8 protein consists of 193 amino acids (23-215) without tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Protein Length: 23-215 a.a.
• Description: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants.
• Bio-activity: Measured in a cell proliferation assay using NR6R­3T3 mouse fibroblast cells. The ED50 for this effect is 0.25-1.5 μg/mL in the presence of 10 μg/mL heparin.
• Molecular Mass: 22.4 kDa
• Product-Related Proteins: 23-215
• Endotoxin: < 0.1 EU/μg of the protein as determined by the LAL method
• Purity: > 95 % as determined by SDS-PAGE
• Storage: At -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: PBS

Gene Information

• Gene Name: FGF8 fibroblast growth factor 8 [ Homo sapiens (human) ]
• Official Symbol: FGF8
• Synonyms: FGF8; fibroblast growth factor 8; HH6; AIGF; KAL6; FGF-8; HBGF-8; fibroblast growth factor 8; Names; androgen-induced growth factor; fibroblast growth factor 8 (androgen-induced); heparin-binding growth factor 8
• Gene ID: 2253
• mRNA Refseq: NM_006119
• Protein Refseq: NP_006110
• MIM: 600483
• UniProt ID: P55075