Active Recombinant Human FGF6 Protein (169 aa)
Cat.No. : | FGF6-412F |
Product Overview : | Recombinant human Fibroblast Growth Factor-6 (rhFGF-6) produced in E. coli is a single non-glycosylated polypeptide chain containing 169 amino acids. A fully biologically active molecule, rhFGF-6 has a molecular mass of 18.8 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques. |
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Species : | Human |
Source : | E.coli |
Protein Length : | 169 |
Description : | Fibroblast Growth Factor-6 (FGF-6) is a cytokine belonging to the heparin-binding FGF family, and is structurally related to other members of FGF family, particularly FGF-4. In vivo, FGF-6 exhibits an expression profile predominantly restricted tothe myogenic lineage, and it preferentially binds to two of the FGF receptors: FGFR1 and FGFR4. FGF-6 functions in muscle regeneration, myoblast proliferation and migration, and muscle differentiation in a dose-dependent manner. In vivo high concentration of recombinant FGF-6 up-regulates and down-regulates FGFR1 and FGFR4, respectively, as FGFR1 promotes the proliferation while FGFR4 promotes the differentiation in the muscle. Besides its dual function in muscle regeneration, FGF-6 may act as a regulator of bone metabolism as well. |
Form : | Sterile Filtered White lyophilized (freeze-dried) powder. |
Bio-activity : | ED50 < 2.5 ng/mL, measured by a cell proliferation assay using 3T3 cells in the presence 1 μg/mL heparin, corresponding to a specific activity of > 4 × 10^5 units/mg. |
Molecular Mass : | 18.8 kDa, observed by reducing SDS-PAGE. |
AA Sequence : | MGTRANNTLLDSRGWGTLLSRSRAGLAGEIAGVNWESGYLVGIKRQRRLYCNVGIGFHLQVLPDGRISGTHEENPYSLLEISTVERGVVSLFGVRSALFVAMNSKGRLYATPSFQEECKFRETLLPNNYNAYESDLYQGTYIALSKYGRVKRGSKVSPIMTVTHFLPRI |
Endotoxin : | < 0.2 EU/μg, determined by LAL method. |
Purity : | > 95% as analyzed by SDS-PAGE and HPLC. |
Storage : | Lyophilized recombinant human Fibroblast Growth Factor-6 (rhFGF-6) remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, rhFGF-6 remains stable up to 2 weeks at 4 centigrade or up to 3 months at -20 centigrade. |
Storage Buffer : | Lyophilized after extensive dialysis against PBS. |
Reconstitution : | Reconstituted in ddH2O at 100 μg/mL. |
Gene Name | FGF6 fibroblast growth factor 6 [ Homo sapiens ] |
Official Symbol | FGF6 |
Synonyms | FGF6; fibroblast growth factor 6; FGF-6; HST-2; HSTF-2; heparin-binding growth factor 6; heparin secretory-transforming protein 2; HST2; HBGF-6; |
Gene ID | 2251 |
mRNA Refseq | NM_020996 |
Protein Refseq | NP_066276 |
MIM | 134921 |
UniProt ID | P10767 |
◆ Recombinant Proteins | ||
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FGF6-176H | Recombinant Human Fibroblast Growth Factor 6 | +Inquiry |
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◆ Cell & Tissue Lysates | ||
FGF6-6237HCL | Recombinant Human FGF6 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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