Active Recombinant Human ERCC3, His-tagged

• Cat.No.: ERCC3-2671H
• Product Overview: Recombinant Human ERCC3 with a His tag is expressed inE. coli.MW: 95±5 KDa.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: ERCC3 is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. It also is the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription.
• Formulation: 20% Glycerol solution at 0.20 mg/ml.
• Activity: ERCC-3 has a 3 prime to 5 prime directed DNA helicase activity.
• Storage: Store at -80°C. At least 1 year at -80°C.

Gene Information

• Gene Name: ERCC3 excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) [ Homo sapiens ]
• Synonyms:
  ERCC3; excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing); BTF2 p89; DNA excision repair protein ERCC-3; DNA repair protein complementing XP-B cells; TFIIH 89 kDa subunit; TFIIH basal transcription factor complex 89 kDa subunit; TFIIH basal transcription factor complex helicase XPB subunit; TFIIH p89; basic transcription factor 2 89 kDa subunit; xeroderma pigmentosum group B-complementing protein; xeroderma pigmentosum, complementation group B; XPB; BTF2; GTF2H; RAD25; TFIIH; EC 3.6.1.-
• Gene ID: 2071
• mRNA Refseq: NM_000122
• Protein Refseq: NP_000113
• MIM: 133510
• UniProt ID: P19447
• Chromosome Location: 2q21
• Pathway: Nucleotide excision repair; DNA Repair; Gene Expression; Transcription; mRNA Processing
• Function: 3"-5" DNA helicase activity; ATP-dependent DNA helicase activity; ATPase activity; DNA-dependent ATPase activity; DNA-dependent ATPase activity; contributes_to RNA polymerase II carboxy-terminal domain kinase activity; damaged DNA binding; protein C-terminus binding; contributes_to protein kinase activity; transcription factor binding