Active Recombinant Human Decorin, HIgG1 Fc-tagged

• Cat.No.: DCN-1702H
• Product Overview: The extracellular domain of human Decorin (AAH05322.1)(Pro18-Lys359) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell.

Specification

• Species: Human
• Source: CHO
• Tag: Fc
• Protein Length: 18-359 a.a.
• Description: The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely relatedin structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a geneduplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a rolein matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing thegrowth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for thisgene. This gene is a candidate gene for Marfan syndrome.
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to modulate collagen fibrillogenesis.
• Molecular Mass: 64kDa (monomer)
• AA Sequence: Pro18-Lys359
• Endotoxin: ≤0.06EU/μg as determined by LAL test.
• Purity: ≥98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: DCN decorin [ Homo sapiens ]
• Official Symbol: DCN
• Synonyms: DCN; decorin; decorin proteoglycan; DSPG2; SLRR1B; PG-S2; bone proteoglycan II; proteoglycan core protein; small leucine-rich protein 1B; dermatan sulphate proteoglycans II; CSCD; PG40; PGII; PGS2
• Gene ID: 1634
• mRNA Refseq: NM_001920
• Protein Refseq: NP_001911
• MIM: 125255
• UniProt ID: P07585
• Chromosome Location: 12q23
• Pathway: TGF-beta signaling pathway, organism-specific biosystem; TGF-beta signaling pathway, conserved biosystem; Validated transcriptional targets of AP1 family members Fra1 and Fra2, organism-specific biosystem
• Function: collagen binding; extracellular matrix binding; glycosaminoglycan binding; protein N-terminus binding