Active Recombinant Human DDB1/CRBN Complex Protein

• Cat.No.: CRBN-001H
• Product Overview: Recombinant Human DDB1/CRBN Complex Protein without tag was expressed in Spodoptera frugiperda, Sf 21 (baculovirus).

Specification

• Description: This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene.
• Source: Insect cell
• Species: Human
• Bio-activity: Typical concentration to support in vitro applications will depend on experimental conditions.
• Molecular Mass: 127 kDa (DDB1), 51 kDa (CRBN)
• Purity: >95% by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  36 months from date of receipt, -70 centigrade as supplied.
  6 months, -20 to -70 centigrade under sterile conditions after opening.
• Storage Buffer: X mg/mL (X μM) in 50 mM HEPES pH 7.5, 200 mM NaCl, 10% (v/v), Glycerol, 1 mM DTT
• Shipping: The product is shipped with dry ice or equivalent.

Gene Information

• Gene Name: CRBN cereblon [ Homo sapiens (human) ]
• Official Symbol: CRBN
• Synonyms: CRBN; cereblon; MRT2; MRT2A; protein cereblon; protein x 0001
• Gene ID: 51185
• mRNA Refseq: NM_016302
• Protein Refseq: NP_057386
• MIM: 609262
• UniProt ID: Q96SW2