Active Recombinant Human CSF3R

• Cat.No.: CSF3R-9295H
• Product Overview: Recombinant Human CSF3R was expressed in CHO Cells.

Specification

• Species: Human
• Source: CHO
• Tag: Non
• Description: Human Granulocyte Colony Stimulating Factor (G-CSF) contains internal disulfide bonds. Among the family of colony-stimulating factors, Granulocyte Colony Stimulating Factor (G-CSF) is the most potent inducer of terminal differentiation to granulocytes and macrophages of leukemic myeloid cell lines. The synthesis of Granulocyte Colony Stimulating Factor (G-CSF) can be induced by bacterial endotoxins, TNF, Interleukin-1 and GM-CSF. Prostaglandin E2 inhibits the synthesis of Granulocyte Colony Stimulating Factor (G-CSF). In epithelial, endothelial, and fibroblastic cells, the secretion of Granulocyte Colony Stimulating Factor (G-CSF) is induced by Interleukin-17.
• Form: Lyophilized after extensive dialysis against PBS.
• Bio-activity: ED50< 0.1="" ng/ml,="" determined="" by="" the="" dose-dependent="" stimulation="" of="" the="" proliferation="" of="" murine="" m-nfs-60="" cells,="" corresponding="" to="" a="" specific="" activity="" of="">1 x 107 units/mg.
• Molecular Mass: 18.7kDa, observed by non-reducing SDS-PAGE.
• AA Sequence: Thr27-Pro200.
• Endotoxin: <0.2 eu/μg,="" determined="" by="" lal="">
• Purity: >95% as analyzed by SDS-PAGE and HPLC.
• Storage: Lyophilized recombinant protein remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhG-CSF should be stable up to 1 week at 4°C or up to 2 months at -20°C.
• Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/ml.

Gene Information

• Gene Name: CSF3R colony stimulating factor 3 receptor (granulocyte) [ Homo sapiens ]
• Official Symbol: CSF3R
• Synonyms: CSF3R; colony stimulating factor 3 receptor (granulocyte); CD114; granulocyte colony-stimulating factor receptor; GCSFR; G-CSF-R; CD114 antigen; G-CSF receptor
• Gene ID: 1441
• mRNA Refseq: NM_000760
• Protein Refseq: NP_000751
• MIM: 138971
• UniProt ID: Q99062
• Chromosome Location: 1p35-p34.3
• Pathway: Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem; Pathways in cancer, organism-specific biosystem
• Function: cytokine receptor activity; receptor activity