Active Recombinant Human CDK18&CCNY, GST-tagged
| Cat.No. : | CDK18&CCNY-826H |
| Product Overview : | Full-length recombinant human PCTK3 and Cyclin Y (2-end) were co-expressed by baculovirus in Sf9 insect cells using N-terminal GST tags. |
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| Description : | PCTK3 or PCTAIRE protein kinase 3 is a member of the cdc2/cdkx subfamily of the ser/thr family of protein kinases. PCTK3 is thought to play a role in terminally differentiated neurons and it contains an N-terminal extension relative to CDC2. PCTK3 is expressed in a variety of human cell lines and tissues. Elevation in the protein levels of PCTAIRE 3 in the temporal cortex of Alzheimer"s disease relative to control brains, have been observed. It is proposed that PCTAIRE 3 is a paired helical filaments-associated kinase that modulates tau phosphorylation. |
| Source : | Sf9 insect cells using baculovirus |
| Species : | Human |
| Tag : | GST |
| Form : | Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Bio-activity : | 46 nmol/min/mg |
| Molecular Mass : | PCTK3 ~76 kDa and Cyclin Y ~64 kDa |
| Protein length : | PCTK3 (Full length) and Cyclin Y (2-end) |
| Purity : | >70% |
| Applications : | Kinase Assay, Western Blot |
| Stability : | 1yr at –70°C from date of shipment |
| Storage : | Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
| Concentration : | 0.1ug/ul |
| Gene Name | CDK18 cyclin-dependent kinase 18 [ Homo sapiens ] |
| Official Symbol | CDK18 |
| Synonyms | CDK18; cyclin-dependent kinase 18; PCTAIRE protein kinase 3 , PCTK3; PCTAIRE3; PCTAIRE protein kinase 3; PCTAIRE-motif protein kinase 3; cell division protein kinase 18; serine/threonine-protein kinase PCTAIRE-3; PCTK3; PCTAIRE; |
| Gene ID | 5129 |
| mRNA Refseq | NM_002596 |
| Protein Refseq | NP_002587 |
| MIM | 169190 |
| UniProt ID | Q07002 |
| Chromosome Location | 1q31-q32 |
| Function | ATP binding; cyclin-dependent protein kinase activity; nucleotide binding; protein serine/threonine kinase activity; signal transducer activity; |
Not For Human Consumption!
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