Active Recombinant Human CCL2, MIgG2a Fc-tagged

• Cat.No.: CCL2-381H
• Product Overview: The extracellular domain of human CCL2 (NP_002973.1) (Gln24-Thr99) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO celL

Specification

• Species: Human
• Source: CHO
• Tag: Fc
• Protein Length: 24-99 a.a.
• Description: This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Chemokines are a superfamilyof secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided intofour subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokineis a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displayschemotactic activity for monocytes and basophils but not for neutrophils or eosinophils. It has been implicatedin the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis andatherosclerosis. It binds to chemokine receptors CCR2 and CCR4.
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR2A.
• Molecular Mass: 35 KDa (monomer)
• AA Sequence: Gln24-Thr99
• Endotoxin: <0.06 eu/μg="" as="" determined="" by="" lal="" test.="">
• Purity: >98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: CCL2 chemokine (C-C motif) ligand 2 [ Homo sapiens ]
• Official Symbol: CCL2
• Synonyms: CCL2; chemokine (C-C motif) ligand 2; SCYA2, small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je); C-C motif chemokine 2; GDCF 2; HC11; MCAF; MCP 1; MCP1; MGC9434; monocyte chemoattractant protein 1; monocyte chemotactic and activating factor; monocyte chemotactic protein 1; homologous to mouse Sig je; monocyte secretory protein JE; small inducible cytokine subfamily A (Cys Cys); member 2; SMC CF; small-inducible cytokine A2; monocyte chemoattractant protein-1; small inducible cytokine subfamily A (Cys-Cys), member 2; small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig-je); MCP-1; SCYA2; GDCF-2; SMC-CF; HSMCR30
• Gene ID: 6347
• mRNA Refseq: NM_002982
• Protein Refseq: NP_002973
• UniProt ID: P13500
• Chromosome Location: 17q11.2-q21.1
• Pathway: Activation of Genes by ATF4, organism-specific biosystem; Chagas disease (American trypanosomiasis), organism-specific biosystem; Chagas disease (American trypanosomiasis), conserved biosystem; Chemokine receptors bind chemokines, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem
• Function: CCR2 chemokine receptor binding; CCR2 chemokine receptor binding; G-protein coupled receptor binding; chemokine activity; heparin binding; protein kinase activity; receptor binding