Active Recombinant Human Bone Morphogenetic Protein 8a

• Cat.No.: BMP8A-591H
• Product Overview: Recombinant Human BMP8Aprotein was expressed in E. coli. Ala264-His402 & Val265-His402.

Specification

• Cat. No.: BMP8A-591H
• Description: BMP8A was firstisolated from a hippocampal library in a screen to identify relatives of BMP-7(OP-1). BMPs are a family of structurally and functionally related proteinsand represent a subfamily of the transforming growth factor β (TGF-β) superfamily.BMPs were originally identified as protein regulators of cartilage and boneformation. They have since been shown to be involved in embryogenesis and morphogenesisof various tissues and organs. BMPs play roles in regulating growth,differentiation, chemotaxis, and apoptosis of various cell types, includingmesenchymal, epithelial, hematopoetic, and neuronal cells.
• Source: E. coli-derived
• Form: Lyophilized from a0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrierprotein.
• N-terminalSequence: Ala264 & Val265
• Molecular Weight: 15.8 kDa (monomer)
• Activity: Measured by itsbinding ability in a functional ELISA. Immobilized rhBMP-8a at 1 μg/mL canbind rhBMPR1B/Fc Chimera with a linear range of 0.15-5 μg/mL. ImmobilizedrhBMPR1A/Fc Chimera at 5 μg/mL can bind rhBMP-8a with a linear range of 3-200ng/mL.
• Endotoxin Level: < 1.0EU per 1 μg of the protein by the LAL method.
• Purity: > 95%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: 20 μg/mL in sterile4 mM HCl containing at least 0.1% human or bovine serum albumin.
• Storage: Use a manual defrostfreezer and avoid repeated freeze-thaw cycles. 12 months from date ofreceipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditionsafter reconstitution. 3 months, -20 to -70°C under sterile conditions afterreconstitution.
• Tag: Non
• Protein length: 264-402;265-402 a.a.

Gene Information

• Gene Name: BMP8A bone morphogeneticprotein 8a [ Homo sapiens ]
• Official Symbol: BMP8A
• Synonyms: BMP8A; bonemorphogenetic protein 8a; bone morphogenetic protein 8A; BMP-8A
• Gene ID: 353500
• mRNA Refseq: NM_181809
• Protein Refseq: NP_861525
• UniProt ID: Q7Z5Y6
• Chromosome Location: 1p35-p32
• Pathway: Hedgehog signalingpathway; TGF-beta signaling pathway
• Function: cytokine activity;growth factor activity