Active Recombinant Human BMX, GST-tagged

• Cat.No.: BMX-1368H
• Product Overview: Recombinant full-length human BMX was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.

Specification

• Description: The BMX gene encodes a non-receptor tyrosine kinase, which may play a role in the growth and differentiation of hematopoietic cells. The BMX gene is located on chromosomal band Xp22.2 between the DXS197 and DXS207 loci. Interestingly, chromosome X also contains the closest relative of BMX, the BTK gene, implicated in X-linked agammaglobulinemia. BMX, is found to induce activation of the Stat signaling pathway.
• Source: Sf9 Cells
• Species: Human
• Tag: GST
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
• Bio-activity: 34 nmol/min/mg
• Molecular Mass: ~110 kDa
• Protein length: Full length
• Purity: >80%
• Applications: Kinase Assay, Western Blot
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.1μg/μl

Gene Information

• Gene Name: BMX BMX non-receptor tyrosine kinase [ Homo sapiens ]
• Official Symbol: BMX
• Synonyms: BMX; BMX non-receptor tyrosine kinase; cytoplasmic tyrosine-protein kinase BMX; ETK; PSCTK3; NTK38 tyrosine kinase; Etk/Bmx cytosolic tyrosine kinase; epithelial and endothelial tyrosine kinase; bone marrow tyrosine kinase gene in chromosome X protein; PSCTK2
• Gene ID: 660
• mRNA Refseq: NM_001721
• Protein Refseq: NP_001712
• MIM: 300101
• UniProt ID: P51813
• Chromosome Location: Xp22.2
• Pathway: Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Apoptosis, organism-specific biosystem; Apoptotic cleavage of cellular proteins, organism-specific biosystem; Apoptotic executionphase, organism-specific biosystem; IL-3 Signaling Pathway, organism-specific biosystem; IL-6 Signaling Pathway, organism-specific biosystem; Signaling events mediated by focal adhesion kinase, organism-specific biosystem
• Function: ATP binding; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein tyrosine kinase activity; signal transducer activity