Active Recombinant Human AKT2, GST-tagged

• Cat.No.: AKT2-802H
• Product Overview: Recombinant Human AKT2, fused with GST-tag at N-terminal, was expressed in Sf9 cells.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Description: This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins.
• Form: Liquid
• Bio-activity: The specific activity was determined to 43 nmol/min/mg as per Activity Assay Protocol.
• Molecular Mass: 85 kDa
• Purity: >90% by densitometry
• Applications: Functional Study; SDS-PAGE
• Storage: Store at -80°C. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.25 mM DTT, 0.1 mM EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 25% glycerol)

Gene Information

• Gene Name: AKT2 v-akt murine thymoma viral oncogene homolog 2 [ Homo sapiens ]
• Official Symbol: AKT2
• Synonyms: AKT2; v-akt murine thymoma viral oncogene homolog 2; PKBB; PRKBB; PKBBETA; RAC-BETA; AKT2 kinase; rac protein kinase beta; Murine thymoma viral (v-akt) homolog-2; EC 2.7.11.1; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; Protein kinase Akt-2; Protein kinase B, beta; PKB beta
• Gene ID: 208
• mRNA Refseq: NM_001626
• Protein Refseq: NP_001617
• MIM: 164731
• UniProt ID: P31751
• Chromosome Location: 19q13.1-q13.2
• Pathway: AKT phosphorylates targets in the cytosol; AMPK signaling; Activation of BH3-only proteins
• Function: ATP binding; kinase activity; protein binding; protein serine/threonine kinase activity