Active Recombinant Full Length Human GSK3A Protein, C-Flag-tagged

• Cat.No.: GSK3A-156HFL
• Product Overview: Recombinant Full Length Human GSK3A Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Bio-activity: In vitro kinase assay (enzyme)
  Thermophoresis assay
• Molecular Mass: 50.8 kDa
• AA Sequence: MSGGGPSGGGPGGSGRARTSSFAEP GGGGGGGGGGPGGSASGPGGTGGGK ASVGAMGGGVGASSSGGGPG GSGGGGSGGPGAGTSFPPPGVKLGR DSGKVTTVVATLGQGPERSQEVAYT DIKVIGNGSFGVVYQARLAE TRELVAIKKVLQDKRFKNRELQIMR KLDHCNIVRLRYFFYSSGEKKDELY LNLVLEYVPETVYRVARHFT KAKLTIPILYVKVYMYQLFRSLAYI HSQGVCHRDIKPQNLLVDPDTAVLK LCDFGSAKQLVRGEPNVSYI CSRYYRAPELIFGATDYTSSIDVWS AGCVLAELLLGQPIFPGDSGVDQLV EIIKVLGTPTREQIREMNPN YTEFKFPQIKAHPWTKVFKSRTPPE AIALCSSLLEYTPSSRLSPLEACAH SFFDELRCLGTQLPNNRPLP
  PLFNFSAGELSIQPSLNAILIPPHL RSPAGTTTLTPSSQALTETPTSSDW QSTDATPTLTNSSTRTRPLEQKLIS EEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Chemokine signaling pathway

Gene Information

• Gene Name: GSK3A glycogen synthase kinase 3 alpha [ Homo sapiens (human) ]
• Official Symbol: GSK3A
• Synonyms: DKFZp686D0638
• Gene ID: 2931
• mRNA Refseq: NM_019884.3
• Protein Refseq: NP_063937.2
• MIM: 606784
• UniProt ID: P49840

Reviews

08/12/2020

Its high purity and integrity ensure reliable and reproducible results, minimizing any potential variability in my experimental outcomes.

09/18/2019

This aspect is crucial in maintaining the scientific rigor of my studies and strengthens the validity of my research findings.

04/10/2019

the manufacturer's commitment to continuous improvement and innovation is evident in their constant efforts to enhance the GSK3A protein.

Q&As

In what ways is GSK3A linked to diabetes?

GSK3A is implicated in insulin signaling and glucose metabolism, and its dysregulation is associated with insulin resistance, a key feature of type 2 diabetes.

Can GSK3A inhibitors have an impact on mood disorders?

Yes, GSK3A is implicated in pathways associated with mood regulation, and inhibitors are being investigated for their potential in treating mood disorders.

Are there GSK3A modulators being explored for anti-inflammatory therapies?

Yes, there is ongoing research to develop GSK3A modulators as potential anti-inflammatory agents.

How does GSK3A contribute to inflammatory conditions?

GSK3A is involved in inflammatory signaling pathways, and its activity is linked to the regulation of inflammatory responses.

Are there any clinical interventions targeting GSK3A for diabetes management?

Researchers are investigating the potential of GSK3A inhibitors to improve insulin sensitivity and glucose homeostasis in diabetes.