Active PLAUR protein-coupled magnetic Beads

• Cat.No.: PLAUR-342M

Specification

• Species: Human
• Source: HEK293
• Appearance: Powder mixture
• Particle size: 2 μm
• Bio-activity: Immobilized 48.8μg Biotinylated Human uPAR protein to 1mg Beads can bind the Anti-uPAR Antibody with an EC50 0.52 μg/mL.
• Coupled amount of protein: ≈1371pmol(48μg) uPAR protein/mg beads
• Capacity: >277pmol (20μg) Anti-uPAR Ab/mg beads
• Formulation: PBS, pH7.4, with 10% Trehalose
• Reconstitution: 2 mL sterile deionized water (1 mg beads/mL)
• Background: Tumors are the result of uncontrolled proliferation of cells in different organs. Tumor development is a multistage process, that includes the generation of primary tumors, separation of tumors from primary sites, degradation of extracellular matrix (ECM), and distant metastasis of tumors. A variety of genes play important roles in the development of tumors, including the cell surface receptor urokinase-type plasminogen activator receptor (uPAR). uPAR is highly expressed in a variety of tumor cells, and a variety of signals regulated by uPAR play significant roles in tumor cell proliferation and metastasis, tumor-related glycolysis, the tumor microenvironment and angiogenesis. Studies have found that some specific drugs and antibodies have unique inhibitory effects on uPAR.
• Application: This product is intended for immunocapture, biopanning and flow cytometry. This product is produced non-sterile.
• Storage: Upon receipt, please store the Beads at -20°C for 1 year in lyophilized state.