Active Native Agaricus bisporus lectin Protein

• Cat.No.: Lectin-1760A
• Product Overview: This product is the unconjugated Agaricus bisporus lectin and has sugar specificity against Gal(b-1,3)GalNAc (T disaccharide).

Specification

• Species: Agaricus bisporus
• Source: Agaricus bisporus
• Tag: Non
• Description: Agaricus bisporus lectin (ABL) isolated from the edible white button mushroom, is composed of two to four very similar isolectins, each a tetramer of approximately 17 kD subunits. This lectin binds the Thomsen-Friedenreich antigen, also called T disaccharide, galactosyl (β-1,3) N-acetylgalactosamine. Unlike peanut agglutinin, which does not bind sialylated T antigen, ABL binds either sialylated or asialylated forms. Also, whereas peanut agglutinin has a proliferative effect on cancer cells, ABL is anti-proliferative, apparently without cytotoxicity. ABL binds all blood groups and O-linked glycans of IgA subclasses. Simple mono- and disaccharides are only marginally inhibitory.
• Form: 10 mM HEPES, pH 7.5, 150 mM NaCl, 0.08% sodium azide
• Bio-activity: Sugar Specificity: Gal(b-1,3)GalNAc (T disaccharide)
• Applications: Immunofluorescence, Glycobiology
• Storage: Refrigerate in the dark.
• Concentration: 2 mg/ml

Gene Information

• Synonyms: Lectin; ABL
• UniProt ID: Q00022