| Cat. No. : |
IL2-028E |
| Description : |
Interleukin2 (IL2) is a Oglycosylated, four μhelix bundle cytokine that has potent stimulatory activity for antigenactivated T cells. It is expressed by CD4+ and CD8+ T cells, μ? T cells, B cells, dendritic cells, and eosinophils. IL2 is best known for its autocrine and paracrine activity on T cells. It drives resting T cells to proliferate and induces IL2 and IL2 Rμ synthesis. It contributes to T cell homeostasis by promoting the Fasinduced death of naïve CD4+ T cells but not activated CD4+ memory lymphocytes. IL2 plays a central role in the expansion and maintenance of regulatory T cells, although it inhibits the development of Th17 polarized cells. Thus, IL2 may be a key cytokine in the natural suppression of autoimmunity. |
| Source : |
E. coli |
| Nterminal Sequence Analysis : |
Met |
| Molecular Mass : |
15 kDa |
| Activity : |
Measured in a cell proliferation assay using CTLL2 mouse cytotoxic T cells. The ED50 for this effect is typically 0.075 0.375 ng/mL. |
| Endotoxin Leve : |
<1.0 EU per 1 μg of the protein by the LAL method. |
| Purity : |
>97%, by SDSPAGE under reducing conditions and visualized by silver stain. |
| Formulation : |
Lyophilized from a 0.2 μm filtered solution in PBS. See Certificate of Analysis for details. |
| Reconstitution : |
Reconstitute at 200 μg/mL in sterile 10 mM Sodium Acetate, pH 4.0. |
| Shipping : |
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
| Storage : |
Use a manual defrost freezer and avoid repeated freezethaw cycles. 1. 12 months from date of receipt, 20 to 70 °C as supplied. 2. 3 month, 2 to 8 °C under sterile conditions after reconstitution. |
| Unitprot ID : |
P60568 |
| Tag : |
Non |
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